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Understanding Cannabis and the Endocannabinoid System

Updated: May 19, 2023


The endocannabinoid system (ECS) is a complex system of neurotransmitters and receptors that plays a crucial role in regulating various physiological processes in the body. The history of the ECS is a fascinating story of scientific discovery and exploration, spanning over several decades. It was first discovered in the 1980s when scientists were studying the effects of tetrahydrocannabinol (THC), the main psychoactive component of cannabis. They found that THC binds to specific receptors in the brain and nervous system, leading to a range of effects, including altered perception, mood, and cognition. Further research revealed that the body produces its own cannabinoids, which are similar in structure to THC and can also bind to the same receptors. These endogenous cannabinoids were named "endocannabinoids," and the receptors they bind to were called "cannabinoid receptors." The ECS is now recognized as a critical regulator of many physiological processes, including appetite, pain, mood, sleep, and immune function. Dysfunction of the ECS has been implicated in several disorders, including obesity, diabetes, chronic pain, and anxiety disorders.


Above, A Single Cannabis Plant


The first endocannabinoid to be identified was anandamide, which was discovered in 1992 by a team of researchers led by Raphael Mechoulam. Anandamide is derived from the Sanskrit word "ananda," which means bliss or happiness, highlighting its potential role in regulating mood and emotions. Since then, several other endocannabinoids have been discovered, including 2-arachidonoylglycerol (2-AG), which is more abundant in the body than anandamide. These endocannabinoids are synthesized on-demand in response to various stimuli and are rapidly broken down by enzymes to prevent overstimulation of the ECS. The discovery of the ECS has led to a better understanding of the therapeutic potential of cannabis and has paved the way for the development of new drugs that target the ECS. These drugs include synthetic cannabinoids, which are designed to mimic the effects of THC, and drugs that target specific components of the ECS, such as the cannabinoid receptors. The discovery of the endocannabinoid system has revolutionized our understanding of how the body works and has opened up new avenues for the development of novel therapeutics. The future of ECS research is promising, and we can expect to uncover even more exciting discoveries in the years to come.



-Sean Despain


New Earth Integration and Plant Medicine

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